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Introduction. Schizophrenia is a chronic psychiatric disorder with a heterogeneous genetic and neurobiological background that influences. guideline for the treatment of patients with schizophrenia. 2018), contributes to morbidity and mortality among individuals with schizophrenia.Read the latest articles of Schizophrenia Research at ScienceDirect.com, Elsevier's leading Pages 1-490 (March 2018) Pages 11-22: Download PDF.