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A change in the DNA molecule. • Process which produces changes in the. DNA that may be inherited. Page 3. Mutagenicity. • = mutagenic activity. • = genotoxicity DNA,1 and “mutagenicity” refers to the process of inducing a mutation. The broader terms “genotoxicity” and “genetic toxicity”,. Ames test is the preferred in vitro primary screening test for gene mutation, which detects most of the mutagens and carcinogens. The assay is based on theHowever, mutagenicity/genotoxicity tests in vitro and in mammalian somatic cells in vivo will also be considered in the sub-divisions of the classification pdf. COM (2010) Guidance: assessment of thresholds for in vivo mutagens. Committee on. Mutagenicity. Available.