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Adult Dosage: Swallow whole. Take with full glass of water. 1 tab every 12 hours. Max: 2 tabs/day. Directions: Do not crush, chew, or break tablet. Take with a full glass of water. This product can be administered without regard for the timing of meals.The standard Mucinex DM dosage for cough and chest congestion is one to two regular-strength tablets (600/30 mg) taken by mouth every 12 hours.