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Consult Tables 1, 2 and 3 in this guide for minimum spacing guidelines based on fire and vessel explosion hazards. Increase spacing where appropriate. Page 3 This Project Engineering Standard covers the basic requirements of the plant layout and spacing of oil & gas refineries, petrochemical and similar chemical. This is an important aspect in the design of chemical and process plants, since a good layout 3.1.3 The guidelines relate to safety, health, welfare.This Technical Measures Document refers to Plant Layout. CIA Guidance for the location and design of occupied building on chemical manufacturing sites, describes Plant Siting and Layout Guidelines with information relevant to the design and layout of new or revised facilities. Once the preliminary design.